De-Risking the Vaccine production
Your Industry, Our Focus
At Eurofins Genomics, we harness the power of Next Generation Sequencing (NGS) to support the development of safer vaccines. NGS is revolutionizing vaccine production by providing comprehensive insights into genetic stability, contamination risks, and overall product integrity.
How NGS supports the production of safer vaccines:
· Adventitious Agent testing
- Metagenomic approaches enable the testing and safe development of various types of vaccines from the R&D stage to the batch release of marketed products.
- By testing the process batch, you may lower the risk of finding a contaminant later in your production stages.
· Identify the integration sites
- To identify the integration sequence, the particular sequence integrated into the cell line and to validate with respect to the product quality during manufacturing.
- Identify mutation in the inserted sequence throughout the process.
· Vaccine Cell line Characterization/ Genetic Stability
- NGS is most powerful and reliable tools for full genome characterization of cell line which enables identity.
- Verify working and master seed stock at genomics level.
- Throughout cell passage, mutations may occur which potentially changes the final vaccine product. To avoid genetic changes, the vaccine manufacturer should test the identity and integrity of master cell banks, extended cell banks, complementing cell lines or recombinant cell lines expressing transgenes throughout the production process.
Frequently Asked Questions ( FAQ's )
How does Next Generation Sequencing (NGS) enhance the safety of vaccine production?
NGS enhances vaccine safety by providing detailed genetic analysis at various stages of production. It allows for the detection of potential contaminants, identification of genetic mutations, and ensures the genetic stability of vaccine cell lines.
What makes NGS superior to traditional methods in identifying adventitious agents in vaccines?
NGS offers a more comprehensive and sensitive approach to detecting adventitious agents compared to traditional methods. It can identify a wide range of known and unknown contaminants in a single analysis, without the need for prior knowledge of the potential contaminants.
How does NGS contribute to the genetic stability of vaccine cell lines throughout the production process?
NGS provides in-depth monitoring of genetic sequences within vaccine cell lines, enabling the detection of mutations that may occur during cell culture and passage. By regularly testing the genomic integrity of master and working cell banks, as well as other critical cell lines, NGS helps ensure that the final vaccine product remains consistent and effective, preventing any genetic drift that could compromise its safety or efficacy.
With Eurofins Genomics' cutting-edge Next Generation Sequencing services, you can trust that your vaccine development process is backed by the highest standards of safety, precision, and genetic integrity, ensuring a safer future for global health.
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